Universität Bonn

A5 - Molecular and structural dynamics of bimodal mRNA expression regulation by the embryonic stem cell differentiation and cancer checkpoint protein TRIM71

Project-related Publications

[P1] P.Q. Duy, S.C. Weise, C. Marini, X. Li, D. Liang, P.J. Dahl, S. Ma, A. Spajic, W. Dong, J. Juusola, E. Kiziltug, A.J. Kundishora, S. Koundal, M.Z. Pedram, L.A. Torres-Fernández, K. Händler, E. De Domenico, M. Becker, T. Ulas, S.A. Juranek, E. Cuevas, L.T. Hao, B. Jux, A.M.M. Sousa, F. Liu, S.-K. Kim, M. Li, Y. Yang, Y. Takeo, A. Duque, C. Nelson-Williams, Y. Ha, K. Selvaganesan, S.M. Robert, A.K. Singh, G. Allington, C.G. Furey, A.T. Timberlake, B.C. Reeves, H. Smith, A. Dunbar, T. DeSpenza Jr., J. Goto, A. Marlier, A. Moreno-De-Luca, X. Yu, W.E. Butler, B.S. Carter, E.M.R. Lake, R.T. Constable, P. Rakic, H. Lin, E. Deniz, H. Benveniste, N. Malvankar, J.I. Estrada-Veras, C.A. Walsh, S.L. Alper, J. Schultze, K. Paeschke, A. Doetzlhofer, F.G. Wulczyn, S.C. Jin, R.P. Lifton, N. Sestan, W. Kolanus, K.T. Kahle*
“Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydro-cephalus”
Nat. Neuroscience 2022, 25, 458–473. DOI: 10.1038/s41593-022-01043-3.

[P2] L.A. Torres-Fernández*, S. Mitschka, T. Ulas, S. Weise, K. Dahm, M. Becker, K. Händler, M. Beyer, J. Windhausen, J.L. Schultze, W. Kolanus
“The stem cell-specific protein TRIM71 inhibits maturation and activity of the pro-differentiation miRNA let-7 via two independent molecular mechanisms”
RNA 2021, 27, 805–828. DOI: 10.1261/rna.078696.121.

[P3] L.A. Torres-Fernández, J. Emich, Y. Port, S. Mitschka, M. Wöste, S. Schneider, D. Fietz, M.S. Oud, S. Di Persio, N. Neuhaus, S. Kliesch, M. Hölzel, H. Schorle, C. Friedrich, F. Tüttelmann*, W. Kolanus*
“TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated with Human Male Infertility”
Front. Cell Dev. Biol.
2021, 9, e658966. DOI: 10.3389/fcell.2021.658966.

[P4] L.A. Torres-Fernández, B. Jux, M. Bille, Y. Port, K. Schneider, M. Geyer, G. Mayer, W. Kolanus*
“The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21”
Nucleic Acids Res. 2019, 47, 11861–11879. DOI: 10.1093/nar/gkz1057.

[P5] S. Mitschka, T. Ulas, T. Goller, K. Schneider, A. Egert, J. Mertens, O. Brüstle, H. Schorle, M. Beyer, K. Klee, J. Xue, P. Günther, K. Bassler, J.L. Schultze, W. Kolanus
“Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71”
Sci. Rep. 2015, 5, 11126. DOI: 10.1038/srep11126.

[P6] D.T.T. Nguyen, D. Richter, G. Michel, S. Mitschka, W. Kolanus, E. Cuevas, F.G. Wulczyn*
“The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation”
Cell Death Differ. 2017, 24, 1063–1078. DOI: 10.1038/cdd.2017.54.

[P7] B. Löer, R. Bauer, R. Bornheim, J. Grell, E. Kremmer, W. Kolanus, M. Hoch*
“The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link”
Nat. Cell Biol. 2008, 10, 422–428. DOI: 10.1038/ncb1704.

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