A6 - RNA structure-function dynamics in transcript-specific translation by the ribosome

Project-related Publications

[P1] K. Leppek, G.W. Byeon, W. Kladwang, H.K. Wayment-Steele, C.H. Kerr, A.F. Xu, D.S. Kim, V.V. Topkar, C. Choe, D. Rothschild, G.C. Tiu, R. Wellington-Oguri, K. Fujii, E. Sharma, A.M. Watkins, J.J. Nicol, J. Romano, B. Tunguz, F. Diaz, H. Cai, P. Guo, J. Wu, F. Meng, S. Shi, E. Participants, P.R. Dormitzer, A. Solórzano, M. Barna*, R. Das*
“Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics”
Nat. Commun. 2022, 13, 1536. DOI: 10.1038/s41467-022-28776-w.

[P2] K. Leppek, G.W. Byeon, K. Fujii, M. Barna*
“VELCRO-IP RNA-seq reveals ribosome expansion segment function in translation genome-wide”
Cell Reports 2021, 34, 108629. DOI: 10.1016/j.celrep.2020.108629.

[P3] K. Leppek, K. Fujii, N. Quade, T.T. Susanto, D. Boehringer, T. Lenarčič, S. Xue, N.R. Genuth, N. Ban*, M. Barna*
“Gene- and species-specific Hox mRNA translation by ribosome expansion segments”
Mol. Cell 2020, 80, 980–995. DOI: 10.1016/j.molcel.2020.10.023.

[P4] K. Leppek, M. Barna*
“An rRNA variant to deal with stress”
Nat. Microbiol. 2019, 4, 382–383. DOI: 10.1038/s41564-019-0396-7.

[P5] K. Leppek, R. Das*, M. Barna*
“Functional 5’ UTR mRNA structures in eukaryotic translation regulation and how to find them”
Nat. Rev. Mol. Cell Biol. 2018, 19, 158–174. DOI: 10.1038/nrm.2017.103.

[P6] D. Simsek, G.C. Tiu, R.A. Flynn, G.W. Byeon, K. Leppek, A.F. Xu, H.Y. Chang, M. Barna*
“The Mammalian Ribointeractome Reveals Ribosome Functional Diversity and Heterogeneity”
Cell 2017, 169, 1051–1065. DOI: 10.1016/j.cell.2017.05.022.

[P7] L. Codutti, K. Leppek, J. Zálešák, V. Windeisen, P. Masiewicz, G. Stoecklin, T. Carlomagno*
“A distinct, sequence-induced conformation is required for recognition of the constitutive decay element RNA by Roquin”
Structure 2015, 23, 1437–1447. DOI: 10.1016/j.str.2015.06.001.

[P8] K. Leppek, G. Stoecklin*
“An optimized streptavidin-binding RNA aptamer for purification of ribonucleoprotein complexes identifies novel ARE-binding proteins”
Nucl. Acids Res. 2014, 42, e13. DOI: 10.1093/nar/gkt956.

[P9] K. Leppek, J. Schott, S. Reitter, F. Poetz, M.C. Hammond, G. Stoecklin*
“Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs”
Cell 2013, 153, 869–881. DOI: 10.1016/j.cell.2013.04.016.

[P10] K. Leppek, J. Schott, G. Stoecklin*
“Protein synthesis and translational control: at eye level with the ribosome”
EMBO Rep. 2011, 12, 1214–1216. DOI: 10.1038/embor.2011.224.