B3 - Immune sensing of conformational dynamics of mRNA structure and chemical editing

Project-related Publications

[P1] C. Wuebben, E. Bartok, G. Hartmann*
“Innate sensing of mRNA vaccines”
Curr. Opin. Immunol. 2022, 79, 102249. DOI: 10.1016/j.coi.2022.102249.

[P2] J. Borggräfe, J. Victor, H. Rosenbach, A. Viegas, C.G.W. Gertzen, C. Wuebben, H. Kovacs, M. Gopalswamy, D. Riesner, G. Steger, O. Schiemann, H. Gohlke, I. Span, M. Etzkorn*
“Time-resolved structural analysis of an RNA-cleaving DNA catalyst”
Nature 2022, 601, 144–149. DOI: 10.1038/s41586-021-04225-4.

[P3] E. Bartok, G. Hartmann*
“Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids”
Immunity 2020, 53, 54–77. DOI: 10.1016/j.immuni.2020.06.014.

[P4] C. Wuebben, M.F. Vicino, M. Mueller, O. Schiemann*
“Do the P1 and P2 hairpins of the Guanidine-II Riboswitch interact?”
Nucleic Acids Res. 2020, 48, 10518–10526. DOI: 10.1093/nar/gkaa703.

[P5] C. Domnick, F. Eggert, C. Wuebben, L. Bornewasser, G. Hagelueken, O. Schiemann*, S. Kath-Schorr*
“EPR Distance measurements on long non-coding RNAs empowered by genetic alphabet expansion transcription”
Angew. Chem. Int. Ed. 2020, 59, 7891–7896. DOI: 10.1002/anie.201916447.

[P6] G. Hartmann
“Nucleic Acid Immunity”
Adv. Immunol. 2017, 133, 121–169. DOI: 10.1016/bs.ai.2016.11.001.

[P7] M. Schlee, G. Hartmann*
“Discriminating self from non-self in nucleic acid sensing”
Nat. Rev. Immunol. 2016, 16, 566–580. DOI: 10.1038/nri.2016.78.

[P8] C. Schuberth-Wagner, J. Ludwig, A.K. Bruder, A.-M. Herzner, T. Zillinger, M. Goldeck, T. Schmidt, J.L. Schmid-Burgk, R. Kerber, S. Wolter, J.-P. Stümpel, A. Roth, E. Bartok, C. Drosten, C. Coch, V. Hornung, W. Barchet, B.M. Kümmerer, G. Hartmann, M. Schlee*
“A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N₁-2'O-Methylated Self RNA“
Immunity 2015, 43, 41–51. DOI: 10.1016/j.immuni.2015.06.015.

[P9] Y. Wang, J. Ludwig, C. Schuberth, M. Goldeck, M. Schlee, H. Li, S. Juranek, G. Sheng, R. Micura, T. Tuschl*, G. Hartmann*, D.J. Patel*
”Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I”
Nat. Struct. Mol. Biol. 2010, 17, 781–787. DOI: 10.1038/nsmb.1863.

[P10] V. Hornung, J. Ellegast, S. Kim, K. Brzózka, A. Jung, H. Kato, H. Poeck, S. Akira, K.-K. Conzelmann, M. Schlee, S. Endres, G. Hartmann*
”5'-Triphosphate RNA is the ligand for RIG-I”
Science 2006, 314, 994–997. DOI: 10.1126/science.1132505.